This screenplay is largely inspired by the "What's grosser than gross?" jokes that I grew up with.
The action takes place as the unsuspecting passengers on an extended flight to the Capital city of Djibouti which is also, head smackingly enough, Djibouti. There's no finer vacation destination than Djibouti in the summertime. Personally, I love any country that sounds like 'yo booty' when pronounced. Eventually, they give in to their ravenous hunger, and thanks to scaled back airline amenities, are only served a cereal breakfast as opposed to a hot meal.
Happily, they crunch away, enjoying every moment of the scenic flight while eating their Bran Flakes. Only, unbeknownst to them, a cargo of biomedical waste has found itself stored on board rather than the cargo hold, and has been unwittingly unleashed in the galley. It's an entire wooden crate full of crusty scabs, and now the box has turned up mysteriously empty. Chaos and havoc ensues, as well as a shortage of airline passenger barf bags.
The next scene finds them making an inexplicable detour to New York City and discovering that grosser than gross is exemplified by a man they witness jumping off the Empire State building and landing on a bicycle with no seat.